Consortium
Saarland University
University of Kuopio
University Szeged
Tel Aviv University
Radboud Universiteit Nijmegen - Stichting Katholieke Universiteit
Göteborgs Universitet
DANONE
Karolinska Institutet
Institute of Physiology, Academy of Sciences of the Czech Republic
VU University Medical Center
Universitätsklinikum Bonn
European Research and Project Office GmbH
New partner!
Hartmann Group
Hartmann group is the most cited scientist for the topic of lipids in Alzheimer’s disease. He was the coordinator of the preceding FP5 LipiDiet project and assistant coordinator of an FP4 EU project by Beyreuther. He is now the coordinator of this project proposal. He has published very highly on different aspects of AD covering a broad range of topics ranging from basic aspects of the molecular and cellular biology of AD over new approaches to the early diagnosis of AD to prospective clinical trials. As an excellent molecular and cellular biologist he shifted over the last decade a major part of his attention towards the lipid metabolism in AD. He provided the first experimental proof that statins lower amyloid levels in vivo, conducted the first (and successful) pilot prospective double blind placebo controlled statin treatment trial to slow down disease progression in AD and identified the molecular mechanism by which cholesterol regulation is linked to Aß production. His work was awarded the prestigious Alois Alzheimer price at the centennial anniversary of the discovery of Alzheimers disease 2006. His broad knowledge base, high international reputation in the field of dementia research, as much as his managing capabilities qualify him as the coordinator for the high demands LipiDiDiet will bring along.
| Contact
Prof. Dr. Tobias Hartmann
Saarland University’s Faculty of Medicine
Kirrberger Straße
Gebäude 90
66421 Homburg (Germany)
Tel: +49-6841-16-4791-8 (lab)
Tel: +49-6841-16-2410-9 (secretary)
Mobile: +49-172-6256-049
Fax: +49-6841-16-2413-7
E-Mail: tobias.hartmann@mx.uni-saarland.de
URL: http://www.neuro-saarland.de |
Fassbender Group
Fassbender is an expert on neuroinflammation and microglia properties, especially in AD. Because inflammation is a very important aspect with a high likelihood to represent on MOA that is actually responsible or contributing to the DHA mediated in disease progression arrest he was asked to join the consortium. He also has a very good background on the role of lipids in AD (Fassbender PNAS 2001). Using in vivo microdialysis techniques, they first demonstrated that aggregated Aß, the main component in senile plaques of AD, but soluble Aß cause pronounced innate immune responses in the living brain. They identified the LPS receptor, as a receptor mediating Aß-induced microglial activation associated with release of strongly neurotoxic molecules and as important receptor for Aß phagocytosis. Taken together this clearly qualifies him as a member of the consortium. Moreover, he is a coordinator of a previous successful EU project (MANAD).
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Prof. Dr. Klaus Fassbender
Saarland University’s Faculty of Medicine
Kirrberger Straße
Gebäude 90
66421 Homburg (Germany)
Tel: +49-6841-1624-130
Fax: +49-6841-1624-1373-7
E-Mail: Klaus.Fassbender@uniklinikum-saarland.de
URL: www.uniklinikum-saarland.de/de/einrichtungen/kliniken_institute/neurologie |
Tanila Group
The Tanila group works on the neurobiological underpinnings of memory impairment both due to subtle age-related changes and as a consequence of beta-amyloid accumulation, as well as on diet and drug based therapies for AD in transgenic mouse models. This is of course the ideal combination one looks for in a project like this.
| Contact
Heikki Tanila
Professor in Molecular Neurobiology
A. I. Virtanen Institute
University of Kuopio
P.O. Box 1627
Neulaniementie 2
70211 Kuopio (Finland)
Tel: +358-17-1620-84
Mobile: +358-44-3637-202
Fax: +358-17-1630-30
E-Mail: Heikki.Tanila@uku.fi
URL: www.uku.fi/aivi |
Soininen Group
The Soininen group has a long-term experience and she has conducted several large projects in molecular epidemiology, genetics, diagnostics and therapy of Alzheimer's disease, as well as neuroimaging in aging and dementia. She has been running large scale population based studies in life style and genetic risk factors of Alzheimer’s disease and mild cognitive impairment. Her list of publication includes 366 papers and over 270 original publications. She is an coordinator of another EU project and has been P.I. in 15 Clinical Drug Trials in the last 6 years. She will be heading the clinical trial project, for which she is ideally suited. Among her staff a Miia Kivipelto, MD, PhD, and docent in neuroepidemiology, who is maybe the most promising young expert on epidemiology of Alzheimer's disease for the topics of our research and already an authority on that topic (51 publications). Kivipelto has positions in Finland and Sweden and will together with Gustafson head the epidemiological studies.
| Contact
Hilkka Soininen
MD, PhD
Professor at the Department of Neurology
Kuopio University Hospital
Building 5 8 floor
P.O. Box 1777
70211 Kuopio (Finland)
Tel: +358-17-1730-12
Fax: +358-17-1730-19
E-Mail: hilkka.soininen@uku.fi
URL: http://www.uku.fi/neuro
URL: http://www.uku.fi/ktk/eng/ |
Penke is a specialist in biochemistry, with vast knowledge of lipid biology and very advanced analysis technologies present. They have a world wide recognition for the very high quality of Aß-peptides they produce and have excellent animal facilities especially for the non mouse models. They also have excellent training facilities for state of the art biochemical equipment.
Penke's group is working with the early diagnosis and prevention of Alzheimer's disease.
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Botond Penke
Department of Medical Chemistry
University of Szeged
Dóm tér 8.
6720 Szeged (Hungary)
Tel: +36-62-5451-35
Mobile: +36-30-4920-24
Fax: +36-62-5459-71
E-Mail: pbotond@mdche.szote.u-szeged.hu
URL: http://www.mdche.u-szeged.hu/indexeng.html
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Our laboratory focuses on the study of cross talk between genetic and environmental risk factors with parituclar emphasis on beta amyloid and apoE4 and the effects thereon of lipida.
Michaelsons group is the leading European specialist for ApoE in dementia mouse models. They have available the latest knock-in mice in all the different allelic variations as well as the KO and transgenic mice. They have established a very large variety to address neuropathological changes including various stimuli. It is known that education is a risk reducing factor in dementia in humans and using the enriched environment scheme Michaelson was able for the first time to demonstrate in vivo that a part of the ApoE 4 dependent pathology is actually dependent on neurogenesis or cognitive input. This lab therefore provides currently the only experimental setting world wide available in which the diets can be tested in the animal in a setting that tries to approximate the human situation. Moreover, the only non-transgenic mouse model ever developed has been generated by Michaelson and represents today a most suitable tool to study in a small animal model – in a short time frame – the aspects of amyloid plaque formation and disintegration on the individual mouse levels at the endogenous genetic background.
| Contact
Daniel M. Michaelson
The Faculty of Life sciences
Tel Aviv University
Tel Aviv 69978 (Israel)
Tel: +972-3-6409-624
Fax: +972-3-6407-643
E-Mail: dmichael@post.tau.ac.il
URL: http://www.tau.ac.il/ |
Radboud University Nijmegen Medical Center | |
Kiliaan group has strong focus on vascular factors in AD and neurodegeneration in general in relation with diet interventions. Kiliaan actually comes from a nutritional industry background and has established her laboratory in academia a few years ago. At the department of Anatomy and department of Cognitive Neuroscience, extensive knowledge is present on haemodynamics and vascular wall biology, (functional) neuroanatomy and histology of the brain and neurodegenerative diseases. The department of Anatomy has a long history of experience with histological, immunohistochemical and electron microscopy techniques, that will be applied in this project to investigate the pathology of blood vessels in the brain. The research group works in very close collaboration with the department of Radiology. The main research focus of the department of Radiology concerns biomedical applications of Magnetic Resonance (MR) with topics haemodynamics and energy metabolism in small rodents and vascular assessment by MRI using various contrast agents. MR instruments with high field power of 7 Tesla and 11.7 Tesla will be used for advanced Arterial Spin Labelling (ASL) MR technology and the so called Diffusion Tensor Imaging (DTI) technology to enable to determine neuron damage in an early phase and connectivity between brain areas and white matter lesions in mice brain.
| Contact
Amanda J Kiliaan, PhD
Assistant Professor at the Department of Anatomy
and Department of Cognitive Neuroscience
Faculty of Medicins, Donders Centre for Neuroscience
Radboud University Nijmegen
Medical Centre
Room M245/0.24
PO Box 9101
6500 HB Nijmegen (The Netherlands)
Tel: +31-2436-1437-8
Fax: +31-2436-1378-9
E-Mail: A.Kiliaan@anat.umc.nl
URL: http://www.ru.nl/english
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Skoog Group
Skoog is the leading authority on vascular dementia epidemiology, the role of vascular factors in AD and vascular cognitive impairment. The group focuses on the epidemiology of AD, with clinical diagnostic and etiologic approaches, and a strong Molecular Epidemiology focus related to use genetic and other biomarkers.
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Ingmar Skoog
Gothenburg University
Institute for Neuroscience and Physiology
Section for Neuroscience and Psychiatry
Wallinsgatan 6, Hus B, Plan 3
431 41 Mölndal (Sweden)
Tel: +46-31-343-8640
Mobile: +46-709-433-681
Fax: +46-31-776-0403
E-Mail: ingmar.skoog@neuro.gu.se
URL: http://www.gu.se/ |
Gustafson Group
Gustafson, author of first reports on relationships between adiposity and AD, cerebrovascular disease, and brain atrophy. Epidemiologic studies in Gothenburg are unique due to the length of time populations have been followed, clinical dementia and cognitive assessments, somatic disorder ascertainment, and routine and detailed risk and protective factor measures. All participants engage in a one day clinical examination, and world-renowned Swedish registry data is used to track those lost to follow-up. The Blennow group adds a strong focus on the measurement and development of blood and cerebrospinal fluid biomarkers for AD and genetic analyses of APOE which are used in the epidemiologic studies. Epidemiologic studies will directly benefit from Prof. Blennow’s determination of CSF and basic science biomarkers.
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Deborah Gustafson
Gothenburg University
Institute for Neuroscience and Physiology
Section for Neuroscience and Psychiatry
Wallinsgatan 6, Hus B, Plan 3
431 41 Mölndal (Sweden)
Tel: +46-31-343-8646
Mobile: +46-768-8088-65
Fax: +46-31-776-0403
E-Mail: Deb.Gustafson@neuro.gu.se
URL: http://www.gu.se/ |
Blennow Group
Blennow is head of the Clinical Neurochemistry Laboratory at Sahlgrenska University Hospital, Göteborg, Sweden. The laboratory has a long-standing experience in CSF analyses for brain disorders. The research group has a focus on CSF biomarkers for AD with a large experience in protein analyses, immunoassays and proteomics/mass spectrometry.
Blennow is beyond doubt the most productive specialist on AD CSF biomarkers and the leading authority. Very recently his breakthrough discovery of very early diagnosis of prodromal/MCI AD caused a shift in the way early AD diagnosis is seen.
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Prof. Kaj Blennow
Gothenburg University
Institute for Neuroscience and Physiology
Section for Neuroscience and Psychiatry
SU/Mölndal, V-huset
431 80 Mölndal (Sweden)
Tel: +46-31-343-1791
Mobile: +46-704-9727-30
Fax: +46-31-343-2426
E-Mail: Kaj.Blennow@neuro.gu.se
URL: http://www.gu.se/
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Danone Research is part of Group Danone, one of the most successful health food companies in the world. Its mission is to bring health through tasty, nutritious and affordable food and beverage products to as many people as possible. Group Danone enjoys leading positions on healthy food in four businesses: fresh dairy products, waters, baby nutrition and medical nutrition. Our Medical Nutrition products range from enteral medical nutrition to advanced medical nutrition for people with special nutritional requirements. The strategy of the Medical Nutrition division is to raise awareness of the value of Advanced Medical Nutrition in the disease management and support of people across the healthcare spectrum; and to develop and market targeted high-value nutrition for every important patient category.
Danone Research – Centre for Specialised Nutrition in Wageningen, The Netherlands, is a science-driven and consumer-led research organization that specializes in Baby Nutrition and Medical Nutrition. We create formulas that provide clinically substantiated growth, development or health benefits to vulnerable consumers – infants, toddlers, elderly and patients. For this purpose we perform research into the complex interaction between nutrition, biological processes and disease mechanisms in the human body. We work in multi-disciplinary teams ranging from immunologists, biologists and microbiologists, to neuroscientists and metabolism experts. We enjoy support from a network of international partners that includes research institutes, universities, hospitals, and industrial suppliers. There is a strong focus on the elderly population and nutritional needs in chronic disease. We see enormous potential in disease targeted nutrition; focusing on improving clinical outcomes by helping to delay the progression of specific conditions, including Alzheimer’s disease.
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Dr. Ladislaus Maria Broersen
Danone Research – Centre for Specialised Nutrition
PO Box 7005
6704 CA Wageningen (The Netherlands)
Tel: +31-317-467854
Fax: +31-317-466-500
E-Mail: laus.broersen@danone.com
URL: http://www.danone.com
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Lars-Olof Wahlund has a long standing high level contribution in the field of dementia and AD. The research group focuses on early diagnostics in dementia and Alzheimer´s disease. Main focus is neuroimaging and MRI. Close collaboration with preclinical and epidemiological competence locally, nationally and internationally. The group has long experience in clinical trials on anti dementia treatment. The research group was the first to publish a clinical trial on Omega 3 fatty acid and Alzheimer’s disease in October 2006. It is obvious from this that this group is a partner of this consortium.
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Prof. Lars-Olof Wahlund
Karolinska Institutet
Department of neurobiology, caring sciences and society
Division of clinical geriatrics
Novum 5th floor
141 86 Stockholm (Sweden)
Tel: +46-8-585-8541-9
Fax: +46-8-585-8547-0
E-Mail: lars-olof.wahlund@ki.se
URL: http://ki.se/ki/jsp/polopoly.jsp?l=en&d=7877
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| Contact
Miia Kivipelto
Karolinska Institutet
Division of geriatric epidemiology
Novum 5th floor
141 86 Stockholm (Sweden)
Tel: +46-73-994-0922
Fax: +46-8-585-8547-0
E-Mail: Miia.Kivipelto@ki.se
URL:
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| Contact
Yvonne Freund-Levi, M.D.
Lic. Cognitive Psycotherapist
Karolinska Institutet
Department of neurobiology, caring sciences and society
Division of clinical geriatrics
Department of Geriatrics
Novum 5th floor
Karolinska University Hospital
114 86 Stockholm (Sweden)
Tel: +46-8-585-8547-2
Fax:
E-Mail: Yvonne.Freund-Levi@ki.se
URL: http://ki.se/ki/jsp/polopoly.jsp?a=39615&d=7877&l=sv
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Institute of Physiology, Academy of Sciences of the Czech Republic | |
A loss of cognitive functions accompanying natural aging and various pathological processes of central nervous system is connected with weakening of cholinergic transmission and disappearance of cholinergic neurons in basal forebrain.
The Dolezal group is concerned with the field of cholinergic physiology, biochemistry and pharmacology and neurotransmission. They will study the effect the diet has on synaptic function. This is a very direct basic science read-out for effectiveness an plays an important role for our in-vitro as much as our in vivo studies to select the right diets before they enter a clinical trial as much as to define the MOA. Dolezal has previously discovered that DHA alters synaptic transmission in the cholinergic pathway.
| Contact
Vladimir Dolezal
Institute of Physiology of the Czech Academy of Sciences, v.v.i.
Department of Neurochemistry
Videnska 1083
14220 Prague 4 (Czech Republic)
Tel: +420-2964-4228-7
Fax: +420-2964-4248-8
E-Mail: dolezal@biomed.cas.cz
URL: http://www.biomed.cas.cz/fgu/en/index.php?jistota=15022008135327
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VU University Medical Center | |
Scheltens has long-lasting research experience in the field of magnetic resonance imaging and biomarkers in dementia with respect to early diagnosis and monitoring of treatment. Experience in leading clinical trials from phase 1 to 3, in a multicentre setting. Most relevant current experience is being PI of the Souvenir study with medical food in mild drug naïve AD patients, placebo-controlled, for 3-6 months. This qualification adds nicely to the other clinical centres involved.
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Philip Scheltens
VU University Medical Center
Deptartment of Neurology/Alzheimer Center
Amsterdam (The Netherlands)
Tel: +31-2044-4074-2
Fax: +31-2044-4071-5
E-Mail: p.scheltens@vumc.nl
URL: http://www.english.vumc.nl/patientcare/
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Lütjohanns group is arguably together with Björkhems group the world leading authority on brain cholesterol metabolites. He has collaborational links with most of the partnering institutions and his contribution will, as previously, ensure that this important topic is addressed by highest standards. His analysis techniques are highly sensitive, straight forward, fast and very robust, fortunately they are quite affordable as well.
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Dieter Lütjohann
Institute of Clinical Chemistry and Pharmacology
University Clinics Bonn
Center Internal Medicine/Lipid Lab/UG68
Sigmund-Freud-Str. 25
53105 Bonn (Germany)
Tel: +49-228-2871-4027 (office)
Tel: +49-228-2871-5272 (lab)
Fax: +49-228-2871-6047
E-Mail: dieter.luetjohann@ukb.uni-bonn.de
URL: http://www.klinpharm.ukb.uni-bonn.de/
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European Research and Project Office GmbH | |
Eurice has been involved in EU Framework Programmes since FP4. As a well experienced and professional project management office, Eurice will support the coordinator in all tasks related to project management and coordination, as well as provide support regarding all innovation-related activities such as dissemination and exploitation of project results.
Eurice is a member of the “European Association of Research Managers and Administrators (EARMA)” and a partner in the IPR helpdesk project which offers basic assistance in Intellectual Property Rights issues and is co-funded by the European Commission.
Eurice has a strong focus on Life Science projects, and the responsible project officer, C.Giehl, has research experience in the field of neuroregeneration and –degeneration herself.
| Contact
Claudia Giehl
European Research and Project Office GmbH
Stuhlsatzenhausweg 69
Science Park 1
66123 Saarbrücken (Germany)
Tel: +49-681-9592-3378
Fax: +49-681-9592-3370
E-Mail: c.giehl@eurice.eu
URL: www.eurice.eu
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Johannes Schröder - University of HeidelbergSection of Geriatric Psychiatry | |
Research of the section of geriatric psychiatry focuses especially on schizophrenia and Alzheimer’s disease (AD). Neurobiological backgrounds and psychosocial influences are of major interest. One of the main focuses of the last few years has been laid on the early detection of AD, working with modern diagnostic methods like MRI and liquor-analysis. Publications have discussed the definition, diagnostic criteria and differential diagnosis of mild cognitive impairment (MCI) as a potential prodromal state of AD. Research within the Interdisciplinary Longitudinal Study on Adult Development and Aging (ILSE) has focused on the epidemiology of psychiatric diseases and its interaction with physical health. Studies like ILSE have the potential of providing precious knowledge about possible risk- and protective factors concerning the development of cognitive impairments, which is of great interest with respect to new intervention and prevention strategies.
Johannes Schröder is the head of the Section auf Geriatric Psychiatry and its associated memory clinic at the University of Heidelberg. Moreover he is the vice-chairman of the ethics committee of the medical department. Johannes Schröder was appointed as a fellow of the Marsilius-Kolleg which is the centre of advanced studies at the University of Heidelberg. Within the Marsilius Kolleg he is the speaker of the interdisciplinary project “Perspectives of Ageing in the Process of Social and Cultural Change”. His long standing contribution to Alzheimer research was honoured with the Alois-Alzheimer price in the year 2006. His research group is an interdisciplinary team with specialists from the field of medicine, psychology, linguistics and neuropsychology.
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Prof. Dr. Johannes Schröder
University of Heidelberg
Section of Geriatric Psychiatry
Voßstr. 4
69115 Heidelberg (Germany)
Tel: +49-6221-56-4403
Tel: +49-6221-56-5468 (secretary)
Fax: +49-6221-56-5327
E-Mail: johannes.schroeder@med.uni-heidelberg.de
URL: http://www.klinikum.uni-heidelberg.de
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